Endocrine Abstracts

Introduction: Metformin is now one of the most common treatments for PCOS. However controversy exists about the usefulness of metformin in PCOS women with normal insulin sensitivity and normal weight. The aim of this study was to compare efficacy of metformin treatment for the purpose of restoration of ovulation in lean and obese women with polycystic ovary syndrome.Design: Thirty-six unovulatory women with PCOS (21 lean with mean body mass index (BMI) 2...

Introduction: Anti-Müllerian hormone (AMH) has an inhibitory role during folliculogenesis, which may contribute to anovulation in polycistic ovary syndrome (PCOS). AMH level has been shown to be a predictor of reproductive response to weight loss and clomiphene citrate in women with PCOS. The aim of this study was to evaluate the role of AMH as a predictor of improvements in menstrual cyclicity and ovulation induction by metformin in lean women with PCOS.<p class="abs...

Background: Endogenous Cushing’s syndrome (CS) is caused by overproduction of cortisol. Current first-line screening tests for CS can produce false positive results due to medication use and stress, rely heavily on patient adherence to sampling instructions, and only measure short-term cortisol exposure which limits sensitivity. In general multiple tests are required to establish a diagnosis. Hair cortisol concentrations (HCC) offer a minimally invasive way to measure lon...

Background: Childhood obesity is an increasing health problem, affecting over 40 million children aged 0–5 years worldwide. It is associated with premature onset of diabetes and cardiovascular disease in adulthood. Pathologically elevated cortisol is known to induce obesity and cardio-metabolic complications, suggesting cortisol is implicated in the onset of obesity. Indeed, recent pilot-studies showed an increase in hair cortisol concentrations in obese adults and adoles...

Introduction: Tumour metastasis to pituitary gland is very rare and constitutes only 1% of all pituitary lesions. Breast and lung cancer are the most common neoplasms reported to metastasize to pituitary gland. Most of the pituitary metastasis are asymptomatic, and thus can be easily overlooked in imaging studies. Polyuria and polydipsia due to diabetes insipidus are the most common sypmtoms in these patients. Patients may also present with visual impairment and symptoms of pa...

Background: Primary hyperparathyroidism (pHPT) is the most prevalent manifestation of multiple endocrine neoplasia type 1 (MEN1). Surgery is the preferred treatment but which type of surgery offers the best chance of cure combined with the lowest risk of postoperative hypoparathyroidism is still uncertain.Aims: Identifying the optimal surgical technique for MEN1 related pHPT. Describing the course of postoperative hypoparathyroidism. To see if a genotype...

Introduction: Elevated levels of cortisol are known to induce a wide range of pathology, e.g. abdominal obesity, type 2 diabetes and cardiovascular disease. Measuring serum and saliva cortisol is limited to one time point. Measurement of cortisol in scalp hair is a recently developed method to measure long term cortisol levels and might reflect cortisol exposure in patients with hyper- or hypo-cortisolism and in healthy persons. Our aims were to explore this measurement of cor...

IntroductionThyroid cancers account for about 2.9%of all cancers. Although it is reported that the risk of developing PTC as the second primary cancer increases after treatment of Hodgkin lymphoma (HL), concomitant PTC and HL are quite rare and to the best of our knowledge we found only three cases in the literature. This case report presents the treatment management and three-year course of a male patient with simultaneous diagnosis of PTC and HL.<p...

Introduction: There is little data about the influence of immunosuppression on the recurrence rate of thyroid cancer. We aimed to evaluate the risk of recurrence and mortality of thyroid cancer after solid organ transplantation.Patients and Methods: We retrospectively evaluated 802 kidney and 283 liver transplant recipients who underwent transplantation between January 1999 and May 2019 in Bașkent University. We identified 14 patients with thyroid c...